Extended and direct evaluation of RT-QuIC assays for Creutzfeldt-Jakob disease diagnosis
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چکیده
منابع مشابه
Extended and direct evaluation of RT‐QuIC assays for Creutzfeldt‐Jakob disease diagnosis
Real-Time Quaking-Induced Conversion (RT-QuIC) testing of human cerebrospinal fluid (CSF) is highly sensitive and specific in discriminating sporadic CJD patients from those without prion disease. Here, using CSF samples from 113 CJD and 64 non-prion disease patients, we provide the first direct and concurrent comparison of our improved RT-QuIC assay to our previous assay, which is similar to t...
متن کاملRapid and Sensitive RT-QuIC Detection of Human Creutzfeldt-Jakob Disease Using Cerebrospinal Fluid
UNLABELLED Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but have required 2.5 to 5 days. Here, an improved RT-QuIC assay is described whic...
متن کاملDiagnosis and reporting of Creutzfeldt-Jakob disease.
FDA's Transmissible Spongiform Encephalopathies Advisory Committee will meet Feb. 20 to hear updates on the implementation of the agency's variant Creutzfeldt-Jakob Disease guidance and its effect on blood supply. FULL STORY>> my name is Terry S. Singeltary Sr., and i lost my mother to hvCJD, one of six known phenotypes of sporadic CJD. i would like to observe this meeting or participate, but h...
متن کاملDiagnosis and Management of Creutzfeldt-Jakob Disease
Introduction Although Creutzfeldt-Jakob disease (CJD) is rare, its rapid course, its infection control implications and the link between bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease (vCJD) make this disease relevant to all clinicians. The emergence of vCJD has prompted an explosion in the amount of research into the disorder, leading to new developments in both diagnos...
متن کاملOptimal diagnostic tests for sporadic Creutzfeldt-Jakob disease based on support vector machine classification of RT-QuIC data
In this work we study numerical construction of optimal clinical diagnostic tests for detecting sporadic Creutzfeldt-Jakob disease (sCJD). A cerebrospinal fluid sample (CSF) from a suspected sCJD patient is subjected to a process which initiates the aggregation of a protein present only in cases of sCJD. This aggregation is indirectly observed in real-time at regular intervals, so that a longit...
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ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2016
ISSN: 2328-9503
DOI: 10.1002/acn3.378